This presentation reviewed the epidemiology and impact of the major subtypes of mood disorders, including bipolar disorder and major depression. Dr. Kathleen Merikangas, Ph.D., Senior Investigator and Chief of the Genetic Epidemiology Branch in the NIMH Division of Intramural Research Programs provided a summary of both environmental and genetic risk factors for mood disorders and presented advances in the application of the tools of molecular genetics to bipolar disorder. The presentation included recent findings from family and genetic studies at the NIMH and approaches to integrate molecular genetics and genetic epidemiology in order to facilitate investigation of the joint influences of genetic factors and environmental influences on the etiology of mood disorders. The series is sponsored by the National Human Genome Research Institute in collaboration with Suburban Hospital, located in Bethesda, MD, and the Johns Hopkins University School of Medicine. https://www.youtube.com/playlist?list=PL1ay9ko4A8slXcrRvAjn5zTm0DBYGiYHF