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Priority health-risk behaviors contribute to the leading causes of morbidity and mortality among youth and adults. The Youth Risk Behavior Surveillance System monitors six categories of priority health behaviors among youth and young adults: 1) behaviors that contribute to unintentional injuries and violence;  2) tobacco use; 3) alcohol and other drug use; 4) sexual behaviors related to unintended pregnancy and sexually transmitted infections; 5) unhealthy dietary behaviors; and 6) physical inactivity. This report summarizes results for 118 health behaviors plus obesity, overweight, and asthma from the 2015 national survey, 37 state surveys, and 19 large urban school district surveys conducted among students in grades nine to 12.