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Findings from two National Institute of Justice-funded studies that focused on high-risk youth highlight the importance of family context in the development of aggression and teen dating violence. These studies summarize the implications of family context for intervention and prevention. Specifically, positive parenting and self-regulation were shown to be crucial protective influences that have effects extending to late adolescence. Furthermore, family-based interventions may be most effective for targeting aggression and teen dating violence in adolescents, particularly for those at higher risk due to parental psychopathology. In particular, programs that focus on improving parents’ mental health, marital conflict, and parenting skills may prove to be particularly beneficial.