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This statistical brief presents estimates based on the use of and expenditures related to mental health disorders among adults ages 18 to 64 in the U.S. civilian, noninstitutionalized population. Mental health care costs for individuals ages 18 to 64 averaged more than $48 billion annually from 2009 to 2011, with 45 percent of the cost (about $22 billion) spent on prescription medicines. On average during that period, 28 million adults per year had health care expenses related to mental health diagnoses.