The All of Us Research Program (formerly known as the Precision Medicine Initiative Cohort Program) will create a community of one million or more people from across the U.S. to improve the future of health. Those who join the program will contribute their health, environment, and lifestyle information over an extended period of time. By gathering information from such a large group of people, researchers will be able to learn how specific factors impact an individual’s health, and disease prevention and treatment. This approach to tailoring health care for each unique individual is called "precision medicine." The research program developers want to hear from everyone about their thoughts and ideas for how to make All of Us a success. Ideas on topics such as participant engagement and communications, health information data security, and the type of data to be collected are welcome from researchers, health care providers, patients, or anyone who wants to contribute to greater knowledge.